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Communication Dans Un Congrès Année : 2006

Fleximags: New tools for micromechanical studies of biomolecular assemblies

Résumé

Magnetic colloidal particles can be readily assembled into one-dimensional structures by field induced dipole-dipole interactions. When interacting polymers are adsorbed on the colloid surfaces, the filaments can be made into permanent flexible filaments, or "fleximags". Their bending properties is then determined by the mechanical properties of the linking polymers. We use a specific dynamical behavior of fleximags to measure their bending stiffness. Biomolecular assemblies extracted from cells and functionalized to interact specifically to the colloids can also act as linkers. We are using this new tool to probe the association of centrin molecules, these proteins being suspected to play an important role in mechanotransduction within cells.
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Dates et versions

hal-00163262 , version 1 (17-07-2007)

Identifiants

  • HAL Id : hal-00163262 , version 1

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Olivia Du Roure, Marc Fermigier, Annie Rousselet. Fleximags: New tools for micromechanical studies of biomolecular assemblies. 231st ACS National Meeting, Mar 2006, United States. ⟨hal-00163262⟩
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