Myosin 1b functions as an effector of EphB signaling to control cell repulsion - Compartimentation et dynamique cellulaires Accéder directement au contenu
Article Dans Une Revue Journal of Cell Biology Année : 2015

Myosin 1b functions as an effector of EphB signaling to control cell repulsion

Marie-Thérèse Prospéri
  • Fonction : Auteur
Priscilla Lépine
  • Fonction : Auteur
Florent Dingli
René Martin
  • Fonction : Auteur
Damarys Loew
Hans-Joachim Knölker
  • Fonction : Auteur

Résumé

Eph receptors and their membrane-tethered ligands, the ephrins, have important functions in embryo morphogenesis and in adult tissue homeostasis. Eph/ephrin signaling is essential for cell segregation and cell repulsion. This process is accompanied by morphological changes and actin remodeling that drives cell segregation and tissue patterning. The actin cortex must be mechanically coupled to the plasma membrane to orchestrate the cell morphology changes. Here, we demonstrate that myosin 1b that can mechanically link the membrane to the actin cytoskeleton interacts with EphB2 receptors via its tail and is tyrosine phosphorylated on its tail in an EphB2-dependent manner. Myosin 1b regulates the redistribution of myosin II in actomyosin fibers and the formation of filopodia at the interface of ephrinB1 and EphB2 cells, which are two processes mediated by EphB2 signaling that contribute to cell repulsion. Together, our results provide the first evidence that a myosin 1 functions as an effector of EphB2/ephrinB signaling, controls cell morphology, and thereby cell repulsion.
Fichier principal
Vignette du fichier
jcb_201501018.pdf (3.35 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-01712201 , version 1 (19-12-2023)

Identifiants

Citer

Marie-Thérèse Prospéri, Priscilla Lépine, Florent Dingli, Perrine Paul-Gilloteaux, René Martin, et al.. Myosin 1b functions as an effector of EphB signaling to control cell repulsion. Journal of Cell Biology, 2015, 210 (2), pp.347 - 361. ⟨10.1083/jcb.201501018⟩. ⟨hal-01712201⟩
70 Consultations
3 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More