Myosin MyTH4-FERM structures highlight important principles of convergent evolution - Compartimentation et dynamique cellulaires Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2016

Myosin MyTH4-FERM structures highlight important principles of convergent evolution

Vicente José Planelles-Herrero
Florian Blanc
  • Fonction : Auteur
Serena Sirigu
  • Fonction : Auteur
Helena Sirkia
  • Fonction : Auteur
Jeffrey Clause
  • Fonction : Auteur
Yannick Sourigues
  • Fonction : Auteur
Daniel Johnsrud
  • Fonction : Auteur
Beatrice Amigues
  • Fonction : Auteur
Marco Cecchini
  • Fonction : Auteur
Susan Gilbert
  • Fonction : Auteur
Margaret Titus
  • Fonction : Auteur

Résumé

Significance Myosins containing MyTH4-FERM (myosin tail homology 4-band 4.1, ezrin, radixin, moesin, or MF) domains in their tails are found in wide range of phylogenetically divergent organisms. Interestingly, evolutionarily distant MF myosins have similar roles in the extension of actin-filled membrane protrusions, such as filopodia, and microtubule binding, suggesting that their core functions have been highly conserved over evolution. A structural analysis of mammalian and Dd myosin MF domains in combination with comparison of diverse MF myosin sequences illustrate how tuning of existing features can give rise to new structures while preserving the general properties of myosin tails. Thus, tinkering with the MF domain enables it to serve as a multifunctional platform for cooperative recruitment of various partners, allowing common properties to arise through convergent evolution.

Dates et versions

hal-04016034 , version 1 (06-03-2023)

Identifiants

Citer

Vicente José Planelles-Herrero, Florian Blanc, Serena Sirigu, Helena Sirkia, Jeffrey Clause, et al.. Myosin MyTH4-FERM structures highlight important principles of convergent evolution. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (21), ⟨10.1073/pnas.1600736113⟩. ⟨hal-04016034⟩
7 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More