Synthesis of chiral polycyclic N -heterocycles via gold(I)-catalyzed 1,6-enyne cyclization/intramolecular nucleophilic addition - Laboratoire de Chimie Moléculaire (LCM) Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2022

Synthesis of chiral polycyclic N -heterocycles via gold(I)-catalyzed 1,6-enyne cyclization/intramolecular nucleophilic addition

Résumé

Cycloisomerization of N-tethered indole- and dihydropyrrole-arylpropargyl substrates into complex polycycles was investigated by using gold(I) catalysis. Enantioselectivities up to 93% ee were obtained in the asymmetric version of this process. DFT calculations rationalized the reactivity observed for the formation of such complex molecular frameworks
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Dates et versions

hal-03835743 , version 1 (01-11-2022)

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Xu Han, Quentin Gaignard-Gaillard, Pascal Retailleau, Vincent Gandon, Arnaud Voituriez. Synthesis of chiral polycyclic N -heterocycles via gold(I)-catalyzed 1,6-enyne cyclization/intramolecular nucleophilic addition. Chemical Communications, 2022, 58 (18), pp.3043-3046. ⟨10.1039/d1cc06388j⟩. ⟨hal-03835743⟩
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