Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Infection and Immunity Année : 2005

Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.

Résumé

Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are indicative of a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent signaling mechanism. Moreover, LM was shown to down-regulate transcription of the metalloproteinase inhibitor TIMP-1, a major endogenous MMP-9 regulator.

Dates et versions

hal-00087166 , version 1 (21-07-2006)

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Elisabeth Elass, Laeticia Aubry, Maryse Masson, Agnés Denys, Yann Guerardel, et al.. Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.. Infection and Immunity, 2005, 73 (10), pp.7064-8. ⟨10.1128/IAI.73.10.7064-7068.2005⟩. ⟨hal-00087166⟩
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