A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2006

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.

Mieko Shiwa
  • Fonction : Auteur

Résumé

In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of NSCs in vitro by a recently developed proteomics technique, the ProteinChip system. In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate. We show herein that Galectin-1 is expressed in a subset of slowly dividing subventricular zone astrocytes, which includes the NSCs. Based on results from intraventricular infusion experiments and phenotypic analyses of knockout mice, we demonstrate that Galectin-1 is an endogenous factor that promotes the proliferation of NSCs in the adult brain.

Domaines

Neurobiologie

Dates et versions

hal-00096031 , version 1 (18-09-2006)

Identifiants

Citer

Masanori Sakaguchi, Tetsuro Shingo, Takuya Shimazaki, Hirotaka James Okano, Mieko Shiwa, et al.. A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (18), pp.7112-7. ⟨10.1073/pnas.0508793103⟩. ⟨hal-00096031⟩
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