Calculating event-triggered average synaptic conductances from the membrane potential. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Neurophysiology Année : 2006

Calculating event-triggered average synaptic conductances from the membrane potential.

Résumé

The optimal patterns of synaptic conductances for spike generation in central neurons is a subject of considerable interest. Ideally, such conductance time courses should be extracted from membrane potential (Vm) activity, but this is difficult because the nonlinear contribution of conductances to the Vm renders their estimation from the membrane equation extremely sensitive. We outline here a solution to this problem based on a discretization of the time axis. This procedure can extract the time course of excitatory and inhibitory conductances solely from the analysis of Vm activity. We test this method by calculating spike-triggered averages of synaptic conductances using numerical simulations of the integrate-and-fire model subject to colored conductance noise. The procedure was also tested successfully in biological cortical neurons using conductance noise injected with dynamic-clamp. This method should allow the extraction of synaptic conductances from Vm recordings in vivo.

Dates et versions

hal-00120638 , version 1 (15-12-2006)

Identifiants

Citer

Martin Pospischil, Zuzanna Piwkowska, Michael Rudolph, Thierry Bal, Alain Destexhe. Calculating event-triggered average synaptic conductances from the membrane potential.. Journal of Neurophysiology, 2006, 97 (3), pp.2544-2522. ⟨10.1152/jn.01000.2006⟩. ⟨hal-00120638⟩

Collections

CNRS
111 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More