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Article Dans Une Revue Nature Structural and Molecular Biology Année : 2006

Oriented loading of FtsK on KOPS.

Résumé

In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of chromosome segregation. DNA transport by FtsK is oriented by 8-base-pair asymmetric sequences ('KOPS'). Here we provide evidence that KOPS promote FtsK loading on DNA and that translocation is oriented at this step.

Dates et versions

hal-00131558 , version 1 (16-02-2007)

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Sarah Bigot, Omar A Saleh, François Cornet, Jean-François Allemand, François-Xavier Barre. Oriented loading of FtsK on KOPS.. Nature Structural and Molecular Biology, 2006, 13 (11), pp.1026-8. ⟨10.1038/nsmb1159⟩. ⟨hal-00131558⟩
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