The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Infection and Immunity Année : 2006

The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.

Jörg Deiwick
  • Fonction : Auteur
Sarah M Gilliland
  • Fonction : Auteur
Thomas Henry
Nele Petermann
  • Fonction : Auteur
Scott R Waterman
  • Fonction : Auteur
David W Holden
  • Fonction : Auteur

Résumé

The facultative intracellular pathogen Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. Inside epithelial cells, Salmonella replicates in vacuoles, which localize in the perinuclear area in close proximity to the Golgi apparatus. Among the effector proteins translocated by the Salmonella pathogenicity island 2-encoded type III secretion system, SifA and SseG have been shown necessary but not sufficient to ensure the intracellular positioning of Salmonella vacuoles. Hence, we have investigated the involvement of other secreted effector proteins in this process. Here we show that SseF interacts functionally and physically with SseG but not SifA and is also required for the perinuclear localization of Salmonella vacuoles. The observations show that the intracellular positioning of Salmonella vacuoles is a complex phenomenon resulting from the combined action of several effector proteins.

Domaines

Immunologie

Dates et versions

hal-00165607 , version 1 (26-07-2007)

Identifiants

Citer

Jörg Deiwick, Suzana P Salcedo, Emmanuel Boucrot, Sarah M Gilliland, Thomas Henry, et al.. The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.. Infection and Immunity, 2006, 74 (12), pp.6965-72. ⟨10.1128/IAI.00648-06⟩. ⟨hal-00165607⟩

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