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Article Dans Une Revue Technology in Cancer Research and Treatment Année : 2007

A study of the immunological response to tumor ablation with irreversible electroporation.

Résumé

Immune cell recruitment during the treatment of sarcoma tumors in mice with irreversible electroporation was studied by immunohistochemistry. Irreversible electroporation is a non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the membrane. Employing irreversible electroporation parameters known to completely ablate the tumors without thermal effects we did not find infiltration of immune cells probably because of the destruction of infiltration routes. We confirm here that immune response is not instrumental in irreversible electroporation efficacy, and we propose that irreversible electroporation may be, therefore, a treatment modality of interest to immunodepressed cancer patients.
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Dates et versions

hal-00172103 , version 1 (14-09-2007)

Identifiants

  • HAL Id : hal-00172103 , version 1
  • PUBMED : 17668937

Citer

Bassim Al-Sakere, Claire Bernat, F. Andre, E. Connault, P. Opolon, et al.. A study of the immunological response to tumor ablation with irreversible electroporation.. Technology in Cancer Research and Treatment, 2007, 6 (4), pp.301-6. ⟨hal-00172103⟩
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