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Article Dans Une Revue European Journal of Cancer Année : 2006

SF-1 overexpression in childhood adrenocortical tumours.

Résumé

The steroidogenic factor 1 (SF-1) gene encodes a transcription factor playing a pivotal role in the regulation of adrenogenital development. We have recently shown that SF-1 is amplified in childhood adrenocortical tumours (ACT). This study was aimed to assess if an increase in SF-1 gene copy number was associated with increased protein levels and to study the correlation between SF-1 expression and ACT clinical parameters. An increased SF-1 copy number was detected in eight of the 10 ACT cases studied. Conversely, the SF-1 protein was found to be overexpressed in all cases, compared to normal age-matched adrenal glands. No significant correlation was found between SF-1 protein levels and its gene copy number. Furthermore, no significant correlation existed with histological grade or with the clinical manifestation or evolution of disease. This data show that SF-1 overexpression is widespread in childhood ACT and is likely to play a role in its pathogenesis.

Dates et versions

hal-00172257 , version 1 (14-09-2007)

Identifiants

Citer

Mara a D Pianovski, Luciane R Cavalli, Bonald C Figueiredo, Savana C L Santos, Mabrouka Doghman, et al.. SF-1 overexpression in childhood adrenocortical tumours.. European Journal of Cancer, 2006, 42 (8), pp.1040-3. ⟨10.1016/j.ejca.2006.01.022⟩. ⟨hal-00172257⟩
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