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Article Dans Une Revue Médecine/Sciences Année : 2006

[ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes]

Résumé

Clinical studies have established the strong link between obesity and type 2 diabetes, especially in children, where the rising prevalence of childhood severe obesity has preceded the recent emergence of early-onset forms of "diabesity". These data suggested a common genetic background shared by both conditions, which was also supported by the identification by genome scans of several diabesity chromosomal regions of linkage. The genetic investigation of early-onset form of familial obesity linkage to chromosome 6q led to the identification of ENPP1, an inhibitor of the insulin receptor, as a possible molecular mechanism behind both obesity and type 2 diabetes. Analysis of the DNA variations of ENPP1 in 6,147 subjects showed association between a combination of variants and both childhood obesity, morbid or moderate obesity in adults and also with type 2 diabetes. This study provides a first molecular basis for the physiopathologic association between severe insulin resistance and obesity, and further type 2 diabetes, and offers a new perspective for prevention and treatment of these conditions.
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Dates et versions

hal-00174458 , version 1 (24-09-2007)

Identifiants

  • HAL Id : hal-00174458 , version 1
  • PUBMED : 16527214

Citer

David Meyre, Philippe Froguel. [ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes]. Médecine/Sciences, 2006, 22 (3), pp.308-12. ⟨hal-00174458⟩

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