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Article Dans Une Revue Current Opinion in Neurobiology Année : 2002

Control of semaphorin signaling.

Résumé

Receptor complexes for the chemorepellent factors of the semaphorin family activate intracellular pathways that trigger actin rearrangements underlying growth cone collapse and repellent behavior. Some evidence has been provided for a complex and dynamic pattern of interaction between members of the small Rho guanosine triphosphatases and plexin proteins that are the receptor subunits responsible for initiating semaphorin signaling. The characterization of new components of semaphorin receptor complexes, the implication of several distinct classes of cytoplasmic effectors, together with the observation of a variety of processes modulating the semaphorin signal have provided a basis for a much improved, but still intricate view of the semaphorin transduction pathways in neurons.
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Dates et versions

hal-00180566 , version 1 (19-10-2007)

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  • HAL Id : hal-00180566 , version 1
  • PUBMED : 12367632

Citer

Valérie Castellani, Geneviève Rougon. Control of semaphorin signaling.. Current Opinion in Neurobiology, 2002, 12 (5), pp.532-41. ⟨hal-00180566⟩
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