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Article Dans Une Revue Médecine/Sciences Année : 2003

[C. elegans as a model for human inherited degenerative diseases]

Résumé

The nematode C. elegans is an established model for developmental biology. Since the early 90's, this simple model organism has been increasingly used for studying human disease pathogenesis. C. elegans models based either on the mutagenesis of human disease genes conserved in this nematode or transgenesis with disease genes not conserved in C. elegans show several features that are observed in mammalian models. These observations suggest that the genetic dissection and pharmacological manipulation of disease-like phenotypes in C. elegans will shed light on the cellular mechanisms that are altered in human diseases, and the compounds that may be used as drugs. This review illustrates these aspects by commenting on two inherited degenerative diseases, Duchenne's muscular dystrophy and Huntington's neurodegenerative disease.
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Dates et versions

hal-00194459 , version 1 (06-12-2007)

Identifiants

  • HAL Id : hal-00194459 , version 1
  • PUBMED : 14691746

Citer

Laurent Ségalat, Christian Néri. [C. elegans as a model for human inherited degenerative diseases]. Médecine/Sciences, 2003, 19 (12), pp.1218-25. ⟨hal-00194459⟩
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