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Article Dans Une Revue Basic and Applied Myology Année : 2001

Coexpression of myosin heavy chain 2b with myosin heavy chain 1-fact or artefact ?

Résumé

In skeletal muscle, pure fibres expressing one myosin heavy chain (MyHC) isoform, and intermediate fibres, expressing two and exceptionally three MyHCs have been described. When skeltal muscle adapts its fibre profile to changed functional demands MyHC isoform transformation follows the pathway: MyHC-1↔MyHC-2a↔MyHC-2x/d↔MyHC-2b. Therefore, in hybrid fibres only successive isoforms from the proposed pathway should coexist. However, jump fibres in which MyHC-1 is co-expressed with MyHC-2x/d have been described recently. The present study describes possible coexpression of MyHC-1with MyHC-2b in transforming as well as in normal control mouse and rat muscle fibres. The study is only descriptive and provides not sufficient proof to exclude the possible artefact resulting from unknown technical reasons.
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Dates et versions

hal-00211786 , version 1 (21-01-2008)

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  • HAL Id : hal-00211786 , version 1

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Ida Erzen, Janez Sketelj, Onnik Agbulut, Denise Angaut-Petit, Gillian S. Butler-Browne. Coexpression of myosin heavy chain 2b with myosin heavy chain 1-fact or artefact ?. Basic and Applied Myology, 2001, 11 (3), pp.119-125. ⟨hal-00211786⟩
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