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Article Dans Une Revue Autophagy Année : 2008

What is the role of autophagy in HIV-1 infection?

Résumé

HIV-1 infection is characterized by a progressive CD4 T cell depletion. It is now accepted that apoptosis of uninfected bystander CD4 T lymphocytes plays a major role in AIDS development. Viral envelope glycoproteins (Env) are mainly involved in inducing this cell death process, but the mechanisms triggered by HIV-1 leading to immunodeficiency are still poorly understood. Recently, we have demonstrated that autophagy is a prerequisite for Env-mediated apoptosis in uninfected CD4 T cells, underlining its role in HIV-1 infection. However, occurrence of autophagy in HIV-1-infected cells has not yet been described. Several hypotheses are discussed, based on the comparison with data from other viral infections.

Dates et versions

hal-00257276 , version 1 (18-02-2008)

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Lucile Espert, Patrice Codogno, Martine Biard-Piechaczyk. What is the role of autophagy in HIV-1 infection?. Autophagy, 2008, 4 (3), pp.273-5. ⟨10.4161/auto.5211⟩. ⟨hal-00257276⟩
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