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Article Dans Une Revue PLoS Pathogens Année : 2008

Nanobacteria are mineralo fetuin complexes

Régis Guieu
  • Fonction : Auteur
Pascal Mansuelle
  • Fonction : Auteur

Résumé

"Nanobacteria" are nanometer-scale spherical and ovoid particles which have spurred one of the biggest controversies in modern microbiology. Their biological nature has been severely challenged by both geologists and microbiologists, with opinions ranging from considering them crystal structures to new life forms. Although the nature of these autonomously replicating particles is still under debate, their role in several calcification-related diseases has been reported. In order to gain better insights on this calciferous agent, we performed a large-scale project, including the analysis of "nanobacteria" susceptibility to physical and chemical compounds as well as the comprehensive nucleotide, biochemical, proteomic, and antigenic analysis of these particles. Our results definitively ruled out the existence of "nanobacteria" as living organisms and pointed out the paradoxical role of fetuin (an anti-mineralization protein) in the formation of these self-propagating mineral complexes which we propose to call "nanons." The presence of fetuin within renal calculi was also evidenced, suggesting its role as a hydroxyapatite nucleating factor.

Domaines

Immunologie
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Dates et versions

hal-00294256 , version 1 (22-02-2017)

Identifiants

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Didier Raoult, Michel Drancourt, Saïd Azza, Claude Nappez, Régis Guieu, et al.. Nanobacteria are mineralo fetuin complexes. PLoS Pathogens, 2008, 4 (2), pp.e41. ⟨10.1371/journal.ppat.0040041⟩. ⟨hal-00294256⟩
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