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Article Dans Une Revue Yeast Année : 2006

The fission yeast spindle orientation checkpoint: a model that generates tension?

Résumé

In all eukaryotes, the alignment of the mitotic spindle with the axis of cell polarity is essential for accurate chromosome segregation as well as for the establishment of cell fate, and thus morphogenesis, during development. Studies in invertebrates, higher eukaryotes and yeast suggest that astral microtubules interact with the cell cortex to position the spindle. These microtubules are thought to impose pushing or pulling forces on the spindle poles to affect the rotation or movement of the spindle. In the fission yeast model, where cell division is symmetrical, spindle rotation is dependent on the interaction of astral microtubules with the cortical actin cytoskeleton. In these cells, a bub1-dependent mitotic checkpoint, the spindle orientation checkpoint (SOC), is activated when the spindles fail to align with the cell polarity axis. In this paper we review the mechanism that orientates the spindle during mitosis in fission yeast, and discuss the consequences of misorientation on metaphase progression.
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Dates et versions

hal-02381437 , version 1 (26-11-2019)

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Yannick Gachet, Céline Reyes, Sherilyn Goldstone, Sylvie Tournier. The fission yeast spindle orientation checkpoint: a model that generates tension?. Yeast, 2006, 23 (13), pp.1015-1029. ⟨10.1002/yea.1410⟩. ⟨hal-02381437⟩
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