Practical asymmetric access to carboxy-differentiated aspartate derivatives via 1,3-dipolar cycloaddition of nitrone with (R)-4-ethyl-N-vinyloxazolidin-2-one
Résumé
A new practical approach to enantioenriched carboxy-differentiated aspartate derivatives was achieved in three steps via the 1,3-dipolar cycloaddition of N-benzyl-α-carbonyloxyethylnitrone with (R)-4-ethyl-N-vinyloxazolidin-2-one and chemoselective nucleophilic displacement of aspartimide under appropriate conditions (racemization less than 3%).