Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Developmental Dynamics Année : 2008

Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans.

Francesca Farina
Adriana A. Alberti
Norman Breuil
  • Fonction : Auteur
Moïse Pinto
  • Fonction : Auteur

Résumé

The adenine nucleotide transporter (ANT) mediates exchange of cytosolic ADP and mitochondrial ATP. Although most species contain more than one ANT family member, it is not known whether their roles in developmental processes are redundant or specific. Here, we show that the Caenorhabditis elegans genome encodes four candidate ant genes (ant-1.1, ant-1.2, ant-1.3, and ant-1.4). We have investigated their spatiotemporal expression patterns and discovered that, whereas ANT-1.1 is a ubiquitously expressed mitochondrial protein, the other three ANT proteins show a restricted range of cell type expression. Moreover, only the disruption of ant-1.1 function, through RNA interference (RNAi), gives a mutant phenotype. Most of the ant-1.1(RNAi) mutant embryos arrest before the morphogenesis stage. Furthermore, ant-1.1 is also required postembryonically because RNAi mutants exhibit small size and life-span extension. Our results suggest that ant-1.1 is the only ant gene strictly required for embryonic and postembryonic development in C. elegans.

Dates et versions

hal-00353492 , version 1 (15-01-2009)

Identifiants

Citer

Francesca Farina, Adriana A. Alberti, Norman Breuil, Monique Bolotin-Fukuhara, Moïse Pinto, et al.. Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans.. Developmental Dynamics, 2008, 237 (6), pp.1668-81. ⟨10.1002/dvdy.21578⟩. ⟨hal-00353492⟩
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