Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Transplantation Année : 2005

Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation.

Marie-Claude Kempf
  • Fonction : Auteur
Axel Andres
  • Fonction : Auteur
Philippe Morel
  • Fonction : Auteur
Pierre-Yves Benhamou
  • Fonction : Auteur
François Bayle
  • Fonction : Auteur
Laurence Kessler
  • Fonction : Auteur
Lionel Badet
  • Fonction : Auteur
Charles Thivolet
  • Fonction : Auteur
Alfred Penfornis
  • Fonction : Auteur
Edith Renoult
  • Fonction : Auteur
Jean-Marcel Brun
  • Fonction : Auteur
Catherine Atlan
  • Fonction : Auteur
Cyrille Colin
  • Fonction : Auteur
Laure Milliat-Guittard
  • Fonction : Auteur
Nadine Pernin
  • Fonction : Auteur
Sandrine Demuylder-Mischler
  • Fonction : Auteur
Christian Toso
  • Fonction : Auteur
Domenico Bosco
  • Fonction : Auteur
Thierry Berney
  • Fonction : Auteur

Résumé

BACKGROUND: Since the Edmonton trial in 2000, increasing numbers of transplant centers have been implementing islet transplantation programs. Some institutions have elected to associate in multicenter networks, such as the Swiss-French GRAGIL (Groupe Rhin-Rh?Alpes-Gen? pour la Transplantation d'Ilots de Langerhans) consortium. METHODS: All pancreata offers to the University of Geneva Cell Isolation and Transplantation Center from within the network in 2002 and 2003 were reviewed. Islet preparations were attributed to the most suitable recipient on a centrally managed waiting list. All shipments were performed by ambulance in less than 5 hr. RESULTS: Over the period of study, 260 pancreata were offered, from a total of 1,304 cadaveric donors in the four allocation regions (20%). Fifty-two patients were on the waiting list at any time during this 2-year period. The percentage of organs offered varied in the range of 0.5% to 42%, depending on region of origin, with a correlation with number of patients on the waiting list in each region. Of these, 104 (40%) were accepted for processing. Ninety-two pancreata were actually processed, resulting in 42 islet preparations being transplanted. The number of international equivalents of transplanted preparations was 378,500+/-16,000 versus 165,400+/-15,400 (P<0.0001) for nontransplanted preparations. Total cold ischemia time was 6+/-0.3 hr for transplanted preparations versus 6.7+/-0.4 hr for nontransplanted preparations (not significant). CONCLUSIONS.: A high rate of pancreas offers, successful isolation, and islet transplantation can be achieved in multicenter networks such as GRAGIL. Such an approach can expand both the donor pool and the recipient population.
Fichier non déposé

Dates et versions

hal-00358799 , version 1 (04-02-2009)

Identifiants

  • HAL Id : hal-00358799 , version 1
  • PUBMED : 15880070

Citer

Marie-Claude Kempf, Axel Andres, Philippe Morel, Pierre-Yves Benhamou, François Bayle, et al.. Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation.. Transplantation, 2005, 79 (9), pp.1200-5. ⟨hal-00358799⟩
77 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More