TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Microbes and Infection Année : 2009

TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection.

Résumé

Mast Cells (MCs) express toll-like receptor 2 (TLR2), a receptor known to be triggered by several major mycobacterial ligands and involved in resistance against Mycobacterium tuberculosis (MTB) infection. This study investigated whether adoptive transfer of TLR2 positive MCs (TLR2(+/+)) corrects the increased susceptibility of TLR2(-/-) mice to MTB infection. TLR2(-/-) mice displayed increased mycobacterial burden, diminished myeloid cell recruitment and proinflammatory cytokine production accompanied by defective granuloma formation. The reconstitution of these mice with TLR2(+/+) MCs, but not TLR2(-/-), confers better control of the infection, promotes the normalization of myeloid cell recruitment associated with reestablishment of the granuloma formation. In addition, adoptive transfer of TLR2(+/+) MC to TLR2(-/-) mice resulted in regulation of the pulmonary levels of IL-beta, IL-6, TNF-alpha, enhanced Th1 response and activated CD8(+) T cell homing to the lungs. Our results suggest that activation of MCs via TLR2 is required to compensate the defect in protective immunity and inability of TLR2(-/-) mice to control MTB infection.

Domaines

Immunologie

Dates et versions

hal-00404933 , version 1 (17-07-2009)

Identifiants

Citer

Daniela Carlos, Fabiani G Frantz, Devandir A Souza-Júnior, Maria C Jamur, Constance Oliver, et al.. TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection.. Microbes and Infection, 2009, epub ahead of print. ⟨10.1016/j.micinf.2009.04.025⟩. ⟨hal-00404933⟩
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