Impaired long term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2009

Impaired long term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1.

Résumé

Zif268 is a transcriptional regulator that plays a crucial role in maintenance of the late phases of hippocampal long-term potentiation (LTP) and consolidation of spatial memories. Because the hippocampal place cell system is essential for long-term spatial memory, we tested the hypothesis that zif268 is required for long-term stability of hippocampal place cell representations by recording CA1 place cells in mice lacking zif268. We found that zif268 gene deletion destabilized the representation of a familiar environment after exposure to a novel environment and impaired the long-term (24 h), but not short-term (1 h), stability of newly formed representations. These impairments could be rescued by repeated exposure to the novel environment, however. These results indicate that zif268 contributes to the long-term stability of spatial representations in CA1 and support the notion that the long-term stability of place cell representations requires transcription-dependent mechanisms similar to those observed in LTP.

Dates et versions

hal-00408793 , version 1 (03-08-2009)

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Citer

Sophie Renaudineau, Bruno Poucet, Serge Laroche, Sabrina Davis, Etienne Save. Impaired long term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1.. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (28), pp.11771-11775. ⟨10.1073/pnas.0900484106⟩. ⟨hal-00408793⟩
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