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Article Dans Une Revue Nature Medicine Année : 2009

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.

François Ghiringhelli
Laetitia Aymeric
  • Fonction : Auteur
Karim Vermaelen
  • Fonction : Auteur
Theocharis Panaretakis
  • Fonction : Auteur
Jean-Luc Perfettini
Frédéric Schlemmer
  • Fonction : Auteur
Martin Uhl
  • Fonction : Auteur
Bernhard Ryffel
  • Fonction : Auteur
  • PersonId : 841831
Nicole M Mclaughlin
  • Fonction : Auteur
Nicole M Haynes
  • Fonction : Auteur
Mark J Smyth
  • Fonction : Auteur
Guido Kroemer

Résumé

The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-gamma (IFN-gamma)-producing T lymphocytes. Here we show that dying tumor cells release ATP, which then acts on P2X(7) purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ('inflammasome'), allowing for the secretion of interleukin-1beta (IL-1beta). The priming of IFN-gamma-producing CD8(+) T cells by dying tumor cells fails in the absence of a functional IL-1 receptor 1 and in Nlpr3-deficient (Nlrp3(-/-)) or caspase-1-deficient (Casp-1(-/-)) mice unless exogenous IL-1beta is provided. Accordingly, anticancer chemotherapy turned out to be inefficient against tumors established in purinergic receptor P2rx7(-/-) or Nlrp3(-/-) or Casp1(-/-) hosts. Anthracycline-treated individuals with breast cancer carrying a loss-of-function allele of P2RX7 developed metastatic disease more rapidly than individuals bearing the normal allele. These results indicate that the NLRP3 inflammasome links the innate and adaptive immune responses against dying tumor cells.

Dates et versions

hal-00419823 , version 1 (25-09-2009)

Identifiants

Citer

François Ghiringhelli, Lionel Apetoh, Antoine Tesniere, Laetitia Aymeric, Yuting Ma, et al.. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.. Nature Medicine, 2009, epub ahead of print. ⟨10.1038/nm.2028⟩. ⟨hal-00419823⟩
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