Influence of the VEGF-A 936C>T germinal polymorphism on tumoral VEGF expression in head and neck cancer. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Pharmacogenomics / Personalized Medicine Année : 2009

Influence of the VEGF-A 936C>T germinal polymorphism on tumoral VEGF expression in head and neck cancer.

Résumé

AIMS: Elevated tumoral vascular endothelial growth factor A (VEGF-A) expression is linked to poor survival in head and neck cancer patients. The aim of the present study was to analyze the influence of VEGF-A gene polymorphisms on tumoral VEGF-A expression and to test their prognostic value in head and neck cancer patients. MATERIALS & METHODS: VEGF-A polymorphisms at position -2578C>A, -1498T>C, -1154G>A, -634G>C and 936C>T were analyzed (PCR-RFLP) in tumoral DNA, along with tumoral VEGF-A expression (ELISA), in 49 Caucasian head and neck cancer patients. RESULTS: A trend towards a difference in tumoral VEGF-A expression depending on 936C>T polymorphism was observed, with a median at 540 pg/mg prot in CT + TT patients (n = 5) versus 940 pg/mg prot in CC patients (n = 44) (p = 0.064). VEGF-A expression was not related to any other polymorphism. Unlike tumoral VEGF-A expression, the analyzed genotypes were not related to patient survival. CONCLUSION: As opposed to tumoral VEGF-A expression, VEGF-A gene polymorphisms are not of prognostic value in head and neck cancer patients. Further studies aimed at confirming the influence of VEGF-A 936C>T germinal polymorphism on tumoral VEGF-A expression are needed.
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Dates et versions

hal-00435702 , version 1 (24-11-2009)

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Jean-Louis Formento, Marie-Christine Etienne-Grimaldi, Mireille Francoual, Gilles Pagès, Cercina Onesto, et al.. Influence of the VEGF-A 936C>T germinal polymorphism on tumoral VEGF expression in head and neck cancer.. Pharmacogenomics / Personalized Medicine, 2009, 10 (8), pp.1277-83. ⟨10.2217/pgs.09.54⟩. ⟨hal-00435702⟩
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