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Article Dans Une Revue Virology Année : 2009

The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.

Résumé

RNA helicase-like receptors MDA-5 but not RIG-I has been shown to be essential for triggering innate immune responses against picornaviruses. However, virus-host co-evolution has selected for viruses capable of replicating despite host cells antiviral defences. In this report, we demonstrate that RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. This effect is mediated by both the viral-encoded 3C protease and caspase proteinase. In addition, we show that RIG-I overexpression confers IFN-beta promoter activation during EMCV infection, in MDA-5 knockout (MDA-5(-/-)) mouse embryo fibroblasts. This induction is followed by a strong inhibition reflecting the ability of EMCV to disrupt RIG-I signalling. Taken together, our data strongly suggest that during evolution RIG-I has been involved for triggering innate immune response to picornavirus infections.

Domaines

Virologie

Dates et versions

hal-00439588 , version 1 (07-12-2009)

Identifiants

Citer

Laura Papon, Alexandra Oteiza, Tadaatsu Imaizumi, Hiroki Kato, Emiliana Brocchi, et al.. The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.. Virology, 2009, 393 (2), pp.311-8. ⟨10.1016/j.virol.2009.08.009⟩. ⟨hal-00439588⟩
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