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Article Dans Une Revue FEBS Letters Année : 2009

Multiple roles of the vesicular-SNARE TI-VAMP in post-Golgi and endosomal trafficking.

Lydia Danglot
Thierry Galli
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Résumé

SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins are the core machinery of membrane fusion. Vesicular SNAREs (v-SNAREs) interact with their target SNAREs (t-SNAREs) to form SNARE complexes which mediate membrane fusion. Here we review the basic properties and functions of the v-SNARE TI-VAMP/VAMP7 (Tetanus neurotoxin insensitive-vesicle associated membrane protein). TI-VAMP interacts with its t-SNARE partners, particularly plasmalemmal syntaxins, to mediate membrane fusion and with several regulatory proteins especially via its amino-terminal regulatory Longin domain. Partners include AP-3, Hrb/(Human immunodeficiency virus Rev binding) protein, and Varp (Vps9 domain and ankyrin repeats containing protein) and regulate TI-VAMP's function and targeting. TI-VAMP is involved both in secretory and endocytic pathways which mediate neurite outgrowth and synaptic transmission, plasma membrane remodeling and lysosomal secretion.

Dates et versions

hal-00441621 , version 1 (16-12-2009)

Identifiants

Citer

Mathilde Chaineau, Lydia Danglot, Thierry Galli. Multiple roles of the vesicular-SNARE TI-VAMP in post-Golgi and endosomal trafficking.. FEBS Letters, 2009, 583 (23), pp.3817-26. ⟨10.1016/j.febslet.2009.10.026⟩. ⟨hal-00441621⟩
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