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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2010

New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.

Arlette Longeon
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Brent R Copp
  • Fonction : Auteur
Mélanie Roué
  • Fonction : Auteur
Alexis Valentin
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  • PersonId : 1098843
Sylvain Petek
Marie-Lise Bourguet-Kondracki
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  • PersonId : 921783

Résumé

Bioassay-directed fractionation of South Pacific marine sponges of the genus Xestospongia has led to the isolation of a number of halenaquinone-type polyketides, including two new derivatives named xestosaprol C methylacetal 7 and orhalquinone 8. Chemical characterization of these two new compounds was achieved by extensive 1D and 2D NMR spectroscopic studies. Evaluation of anti-phospholipase A(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed. Orhalquinone 8 displayed a significant inhibition of both human and yeast farnesyltransferase enzymes, with IC(50) value of 0.40 microM and was a moderate growth inhibitor of Plasmodium falciparum.

Dates et versions

hal-00522053 , version 1 (29-09-2010)

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Citer

Arlette Longeon, Brent R Copp, Mélanie Roué, Joëlle Dubois, Alexis Valentin, et al.. New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.. Bioorganic and Medicinal Chemistry, 2010, 18 (16), pp.6006-11. ⟨10.1016/j.bmc.2010.06.066⟩. ⟨hal-00522053⟩
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