Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue International Journal for Parasitology Année : 2008

Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis.

Résumé

Blastocystis hominis is an anaerobic parasite of the human intestinal tract belonging to the Stramenopile group. Using genome sequencing project data, we describe here the complete sequence of a 29,270-bp circular DNA molecule that presents mitochondrial features (such as oxidative phosphorylation complex I subunits) but lacks complexes III, IV and V. Transmission electron microscopy analyses reveal that this molecule, as well as mitochondrial (NADH:ubiquinone oxidoreductase subunit 7 (NAD7), beta-succinyl-CoA synthetase (beta-SCS)) and hydrogenosomal (pyruvate ferredoxin oxido-reductase (PFOR), iron-hydrogenase) proteins, are located within double-membrane surrounded-compartments known as mitochondria-like organelles (MLOs). As there is no evidence for hydrogen production by this organism, we suggest that MLOs are more likely anaerobic mitochondria.
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Dates et versions

hal-00527813 , version 1 (20-10-2010)

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Ivan Wawrzyniak, Michaël Roussel, Marie Diogon, Arnaud Couloux, Catherine Texier, et al.. Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis.. International Journal for Parasitology, 2008, 38 (12), pp.1377-1382. ⟨10.1016/j.ijpara.2008.06.001⟩. ⟨hal-00527813⟩
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