Chiral phosphoric acid-catalyzed enantioselective transfer hydrogenation of ortho-hydroxyaryl alkyl N-H ketimines. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2010

Chiral phosphoric acid-catalyzed enantioselective transfer hydrogenation of ortho-hydroxyaryl alkyl N-H ketimines.

T .B. Nguyen
Qian Wang

Résumé

The first enantioselective chiral phosphoric acid-catalyzed transfer hydrogenation of unprotected ortho-hydroxyaryl alkyl N-H ketimines using Hantszch di-tert-butyl ester as a reductant is reported. A variety of ortho-hydroxybenzylamines were obtained in good to excellent yields and enantiomeric excesses.

Domaines

Chimie organique
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Dates et versions

hal-00530103 , version 1 (27-10-2010)

Identifiants

Citer

T .B. Nguyen, Hadjira Bousserouel, Qian Wang, Françoise Guéritte. Chiral phosphoric acid-catalyzed enantioselective transfer hydrogenation of ortho-hydroxyaryl alkyl N-H ketimines.. Organic Letters, 2010, 12 (20), pp.4705-7. ⟨10.1021/ol102043x⟩. ⟨hal-00530103⟩
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