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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2011

Design, synthesis and biological evaluation of new thalidomide analogues as TNF-alpha and IL-6 production inhibitors

Résumé

Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Among these compounds, two analogues containing sulfonyl group displayed interesting downregulation of TNF-alpha and IL-6 production. (C) 2010 Elsevier Ltd. All rights reserved.

Dates et versions

hal-00610445 , version 1 (22-07-2011)

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Citer

Charlotte Chaulet, Cecile Croix, David Alagille, Sylvain Normand, Adriana Delwail, et al.. Design, synthesis and biological evaluation of new thalidomide analogues as TNF-alpha and IL-6 production inhibitors. Bioorganic and Medicinal Chemistry Letters, 2011, 21 (3), pp.1019-1022. ⟨10.1016/j.bmcl.2010.12.031⟩. ⟨hal-00610445⟩
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