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Article Dans Une Revue Mini-Reviews in Medicinal Chemistry Année : 2009

First Mariner Mos1 Transposase Inhibitors

Résumé

We described chemical inhibitors of Mos1 transposition. Some were already known to affect a related prokaryotic transposase (Tn5) or HIV-1 integrase, whereas the other were new compounds in this field. The new compounds were all organized around a bis-(heteroaryl) maleimides scaffold. Their mechanism of action depended on the chemical substitutions on the scaffold. The cross-activity, between HIV-1 integrase and Mos1 transposase, of the new group of inhibitors showed that Mos1 transposase could constitute an excellent surrogate HIV-1 inhibitor screen.
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Dates et versions

hal-00614894 , version 1 (17-08-2011)

Identifiants

  • HAL Id : hal-00614894 , version 1

Citer

Nicolas Bouchet, Julien Bischerour, Stephanie Germon, Jerome Guillard, Mathieu Dubernet, et al.. First Mariner Mos1 Transposase Inhibitors. Mini-Reviews in Medicinal Chemistry, 2009, 9 (4), pp.431-439. ⟨hal-00614894⟩
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