Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2011

Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones

Résumé

We report here the synthesis and in vitro antitubercular activity of a new series of ferrocenyl derivatives. The quinoline-ferrocene hybrid 5 exhibited significant activity (MIC = 2.5-5 μg/ml) against Mycobacterium tuberculosis. Results indicate that such hybrid compounds provide an efficient approach for future pharmacological developments to fight against tuberculosis. Moreover, the antimalarial drug candidate ferroquine (FQ, SSR97193) was also evaluated mainly because of its structural similarity. FQ was found to display moderate inhibitory activity (MIC = 10-15 μg/ml) against M. tuberculosis. This new drug may offer an interesting alternative in endemic area where malaria and tuberculosis coexist.

Dates et versions

hal-00641742 , version 1 (16-11-2011)

Identifiants

Citer

A. Mahajan, Laurent Kremer, S. Louw, Yann Guerardel, Kelly Chibale, et al.. Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones. Bioorganic and Medicinal Chemistry Letters, 2011, 21 (10), pp.2866-2868. ⟨10.1016/j.bmcl.2011.03.082⟩. ⟨hal-00641742⟩
82 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More