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Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2012

IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.

Résumé

Analysis of two clonally related multiresistant Pseudomonas aeruginosa isolates led to the identification of a novel IMP-type metallo-β-lactamase. IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity). The bla(IMP-29) gene cassette was carried by a class 1 integron in strain 10.298, while in strain 10.266 it was located in a rearranged DNA region on a 30-kb conjugative plasmid. Biochemical analysis confirmed that IMP-29 efficiently hydrolyzed carbapenems.

Dates et versions

hal-00668254 , version 1 (09-02-2012)

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Katy Jeannot, Laurent Poirel, Marjorie Robert-Nicoud, Pascal Cholley, Patrice Nordmann, et al.. IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.. Antimicrobial Agents and Chemotherapy, 2012, 56 (4), pp.2187-90. ⟨10.1128/AAC.05838-11⟩. ⟨hal-00668254⟩
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