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Article Dans Une Revue Nucleus Année : 2011

Heterochromatin maintenance and establishment: lessons from the mouse pericentromere.

Résumé

Defined as a chromatin structure that remains condensed throughout the cell cycle heterochromatin is generally transcriptionally silent and is characterized by a specific molecular signature. Constitutive heterochromatin at the pericentromere is a conserved feature throughout evolution, which impacts genome stability. Here, we will summarize recent advances in our understanding of the dynamics of mouse pericentric heterochromatin during the cell cycle and development. Comparison with heterochromatin maintenance in fission yeast will enable discussions of the common basic principles and various mechanisms exploited in the distinct organisms.
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Dates et versions

hal-00742945 , version 1 (17-10-2012)

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Geneviève Almouzni, Aline V Probst. Heterochromatin maintenance and establishment: lessons from the mouse pericentromere.. Nucleus, 2011, 2 (5), pp.332-8. ⟨10.4161/nucl.2.5.17707⟩. ⟨hal-00742945⟩
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