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Article Dans Une Revue Journal of Nanoparticle Research Année : 2012

Bivalent alkyne-bisphosphonate as clickable and solid anchor to elaborate multifunctional iron oxide nanoparticles with microwave enhancement

Résumé

We report the elaboration of clickable superparamagnetic nanoparticles that act as a scaffold for further modifications by click chemistry. This nano platform is easily obtained by coating iron oxide nanoparticle γ-Fe2O3, with a new bifunctional molecule (1-hydroxy-1-phosphonopent-4-ynyl)phosphonic acid (HMBPyne). The HMBP and the alkyne functions act respectively as anchoring surface group and click chemistry functionality. We evaluate the functionalization of this new "clickable" nanoplateform using Huisgen 1,3-cycloaddition as model reaction and demonstrate the potential of microwave irradiation to increase the grafting yield. The effectiveness of click chemistry for the modification of mNPs is explored with a diverse array of functional species.

Dates et versions

hal-00768664 , version 1 (22-12-2012)

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Citer

Erwann Guenin, J. Hardouin, Yoann Lalatonne, Laurence Motte. Bivalent alkyne-bisphosphonate as clickable and solid anchor to elaborate multifunctional iron oxide nanoparticles with microwave enhancement. Journal of Nanoparticle Research, 2012, pp.965. ⟨10.1007/s11051-012-0965-7⟩. ⟨hal-00768664⟩
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