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Article Dans Une Revue Journal of Applied Physiology Année : 2013

Effect of contrasted levels of habitual physical activity on metabolic flexibility.

Résumé

The factors regulating the body's ability to switch from fat to carbohydrate oxidation in response to fuel availability changes, or metabolic flexibility (MF), are currently intensively investigated in the context of metabolic diseases. Although numerous metabolic diseases are associated with sedentary behaviours and metabolic inflexibility, the effect of habitual physical activity level (PAL) on MF regulation is surprisingly poorly known. We investigated how PAL affects MF in cross-sectional and interventional studies. MF was assessed in 44 subjects: normal-weight and overweight sedentary men submitted to 2-months of exercise at current recommendations, normal-weight active men submitted to 1-month of reduced PAL and normal-weight women submitted to 1-month of bed-rest with or without exercise. MF was evaluated, before and after interventions, following two standard meals as the relationship between individual mathematical variances in insulin and non-protein respiratory quotient (NPRQ) daily kinetics. Daily NPRQ and insulin variances differed according to habitual PAL (p=0.002 and p=0.009, respectively); active subjects had higher variances in NPRQ for lower variances in insulin than sedentary subjects, indicating a better MF. Detraining increased insulin variance (p=0.009) and decreased NPRQ variance (p=0.003), while training tended to have opposite effects. Insulin and NPRQ variances were negatively related along the PAL continuum (R(2)=0.70, p<0.001). Variance in NPRQ was also positively related to PAL (R(2)=0.52, p<0.001). By assessing MF with mathematical surrogates in conditions of daily pattern in meal's intake, we showed that habitual PAL is associated with MF status and that MF is modulated by changes in PAL.
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Dates et versions

hal-00783196 , version 1 (31-01-2013)

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Audrey Bergouignan, Edwina Antoun, Iman Momken, Dale Alan Schoeller, Guillemette Gauquelin-Koch, et al.. Effect of contrasted levels of habitual physical activity on metabolic flexibility.. Journal of Applied Physiology, 2013, 114 (3), pp.371-379. ⟨10.1152/japplphysiol.00458.2012⟩. ⟨hal-00783196⟩
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