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Article Dans Une Revue Research in Microbiology Année : 2011

Extreme reduction and compaction of microsporidian genomes.

Résumé

Microsporidia are fungi-related obligate intracellular parasites with a highly reduced and compact genome, as for Encephalitozoon species which harbor a genome smaller than 3 Mbp. Genome compaction is reflected by high gene density and, for larger microsporidian genomes, size variation is due to repeat elements that do not drastically affect gene density. Furthermore, these pathogens present strong host dependency illustrated by extensive gene loss. Such adaptations associated with genome compaction induced gene size reduction but also simplification of cellular processes such as transcription. Thus, microsporidia are excellent models for eukaryotic genome evolution and gene expression in the context of host-pathogen relationships.

Dates et versions

hal-00814808 , version 1 (17-04-2013)

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Eric Peyretaillade, Hicham El Alaoui, Marie Diogon, Valérie Polonais, Nicolas Parisot, et al.. Extreme reduction and compaction of microsporidian genomes.. Research in Microbiology, 2011, 162 (6), pp.598-606. ⟨10.1016/j.resmic.2011.03.004⟩. ⟨hal-00814808⟩
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