Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular zone. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Neuroscience Année : 2012

Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular zone.

Résumé

In the postnatal forebrain, the subventricular zone (SVZ) contains a pool of undifferentiated cells, which proliferate and migrate along the rostral migratory stream (RMS) to the olfactory bulb and differentiate into granule cells and periglomerular cells. Plexin-B2 is a semaphorin receptor previously known to act on neuronal proliferation in the embryonic brain and neuronal migration in the cerebellum. We show here that, in the postnatal and adult CNS, Plexin-B2 is expressed in the subventricular zone lining the telencephalic ventricles and in the rostral migratory stream. We analyzed Plxnb2(-/-) mice and found that there is a marked reduction in the proliferation of SVZ cells in the mutant. Plexin-B2 expression is downregulated in the olfactory bulb as interneurons initiate radial migration. BrdU labeling and GFP electroporation into postnatal SVZ, in addition to time-lapse videomicroscopy, revealed that neuroblasts deficient for Plexin-B2 migrate faster than control ones and leave the RMS more rapidly. Overall, these results show that Plexin-B2 plays a role in postnatal neurogenesis and in the migration of SVZ-derived neuroblasts.

Dates et versions

hal-00843342 , version 1 (11-07-2013)

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Citer

Bhaskar Saha, Athéna R Ypsilanti, Camille Boutin, Harold Cremer, Alain Chédotal. Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular zone.. Journal of Neuroscience, 2012, 32 (47), pp.16892-905. ⟨10.1523/JNEUROSCI.0344-12.2012⟩. ⟨hal-00843342⟩
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