Prognostic impact of day 15 blast clearance in risk-adapted remission induction chemotherapy for younger patients with acute myeloid leukemia: long term results of the multicenter prospective LAM-2001 trial by the GOELAMS study group. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Haematologica Année : 2013

Prognostic impact of day 15 blast clearance in risk-adapted remission induction chemotherapy for younger patients with acute myeloid leukemia: long term results of the multicenter prospective LAM-2001 trial by the GOELAMS study group.

Sarah Bertoli
Pierre Bories
Marie C Béné
  • Fonction : Auteur
Sylvie Daliphard
  • Fonction : Auteur
Norbert Vey
Vincent Leymarie
  • Fonction : Auteur
Didier Bouscary
  • Fonction : Auteur
Jean Luc Harousseau
  • Fonction : Auteur
Jean Yves Cahn
  • Fonction : Auteur
Christian Récher

Résumé

: Early response to chemotherapy has a major prognostic impact in acute myeloid leukemia patients treated with a double induction strategy. Less is known about patients treated with standard-dose cytarabine and anthracycline. We designed a risk-adapted remission induction regimen in which a second course of intermediate-dose cytarabine was delivered after standard 7+3 only if patients had 5% or more bone marrow blasts fifteen days after chemotherapy initiation (d15-blasts). Of 823 included patients, 795 (96.6%) were evaluable. Five hundred and forty five patients (68.6%) had less than 5% d15-blasts. Predictive factors for high d15-blasts were white blood cell count (p<0.0001) and cytogenetic risk (p<0.0001). Patients with fewer than 5% d15-blasts had a higher complete response rate (91.7% vs 69.2%, p<0.0001) and a lower induction death rate (1.8% vs 6.8%, p=0.001). Five-year event-free (48.4% vs 25%, p<0.0001), relapse-free (52.7% vs 36.9%, p=0.0016) and overall survival (55.3% vs 36.5%, p<0.0001) were significantly higher in patients with d15-blasts lower than 5%. Multivariate analyses identified d15-blasts and cytogenetic risk as independent prognostic factors for the three endpoints. Failure to achieve early blast clearance remains a poor prognostic factor even after early salvage. By contrast, early responding patients have a favorable outcome without any additional induction course. NCT01015196.

Domaines

Hématologie

Dates et versions

hal-00854975 , version 1 (28-08-2013)

Identifiants

Citer

Sarah Bertoli, Pierre Bories, Marie C Béné, Sylvie Daliphard, Bruno Lioure, et al.. Prognostic impact of day 15 blast clearance in risk-adapted remission induction chemotherapy for younger patients with acute myeloid leukemia: long term results of the multicenter prospective LAM-2001 trial by the GOELAMS study group.. Haematologica, 2013, epub ahead of print. ⟨10.3324/haematol.2013.091819⟩. ⟨hal-00854975⟩
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