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Article Dans Une Revue Chemical Communications Année : 2013

Direct N-cyclopropylation of secondary acyclic amides promoted by copper

Résumé

The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.

Domaines

Chimie organique
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Dates et versions

hal-00877292 , version 1 (28-10-2013)

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Emilie Racine, Florian Monnier, Jean-Pierre Vors, Marc Taillefer. Direct N-cyclopropylation of secondary acyclic amides promoted by copper. Chemical Communications, 2013, 49, pp.7412. ⟨10.1039/C3CC42575D⟩. ⟨hal-00877292⟩
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