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Article Dans Une Revue International Journal of Pharmaceutics Année : 2013

Polymeric micelles based on poly(methacrylic acid) block-containing copolymers with different membrane destabilizing properties for cellular drug delivery

Résumé

Poly(methacrylic acid)-b-poly(ethylene oxide) are double hydrophilic block copolymers, which are able to form micelles by complexation with a counter-polycation, such as poly-l-lysine. A study was carried out on the ability of the copolymers to interact with model membranes as a function of their molecular weights and as a function of pH. Different behaviors were observed: high molecular weight copolymers respect the membrane integrity, whereas low molecular weight copolymers with a well-chosen asymmetry degree can induce a membrane alteration. Hence by choosing the appropriate molecular weight, micelles with distinct membrane interaction behaviors can be obtained leading to different intracellular traffics with or without endosomal escape, making them interesting tools for cell engineering. Especially micelles constituted of low molecular weight copolymers could exhibit the endosomal escape property, which opens vast therapeutic applications. Moreover micelles possess a homogeneous nanometric size and show variable properties of disassembly at acidic pH, of stability in physiological conditions, and finally of cyto-tolerance.

Dates et versions

hal-00881053 , version 1 (07-11-2013)

Identifiants

Citer

Naila Mebarek, Anne Aubert-Pouëssel, Corine Gerardin, Rita Vicente, Jean-Marie Devoisselle, et al.. Polymeric micelles based on poly(methacrylic acid) block-containing copolymers with different membrane destabilizing properties for cellular drug delivery. International Journal of Pharmaceutics, 2013, 454 (2), pp.611-620. ⟨10.1016/j.ijpharm.2013.06.014⟩. ⟨hal-00881053⟩
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