Encapsulation of complementary model drugs in spray-dried nanostructured materials - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Sol-Gel Science and Technology Année : 2013

Encapsulation of complementary model drugs in spray-dried nanostructured materials

Résumé

Two model drugs of different physico-chemical and pharmaceutical properties (ibuprofen, acetaminophen) have been incorporated together or separately in silicabased microspheres using sol-gel and spray-drying processes. A variable amount of a neutral surfactant Brij-56 has also been added. The properties of the microspheres vary significantly depending on their composition. Three kinds of texture are identified: (1) silica containing spheroid nano-domains (formed by ibuprofen; diameters between 20 and 100 nm), (2) silica containing worm-like mesophases (formed by Brij-56 and both model drugs, typical correlation distances *6 nm), (3) silica intimately mixed with the drug (acetaminophen) without visible phase-separation. The kinetics of drug release in simulated intestinal fluid strongly depend on these textures. The association of ibuprofen and acetaminophen in a single type of microsphere and without surfactant favours a concomitant release. Possible mechanisms of materials' formation are discussed.

Domaines

Matériaux

Dates et versions

hal-00921864 , version 1 (22-12-2013)

Identifiants

Citer

Mohamed Fatnassi, Corine Tourné-Péteilh, Pradial Peralta, Thomas Cacciaguerra, Philippe Dieudonné, et al.. Encapsulation of complementary model drugs in spray-dried nanostructured materials. Journal of Sol-Gel Science and Technology, 2013, 68 (2), pp.307-316. ⟨10.1007/s10971-013-3170-y⟩. ⟨hal-00921864⟩
171 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More