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Article Dans Une Revue Advanced Healthcare Materials Année : 2013

Antibody-Functionalized Magnetic Polymersomes: In vivo Targeting and Imaging of Bone Metastases using High Resolution MRI

Résumé

Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody‐labeled polymersomes at the tumor site.

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Polymères Imagerie
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Dates et versions

hal-00926530 , version 1 (03-11-2018)

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Line Pourtau, Hugo de Oliveira, Julie Thevenot, Yali Wan, Alain R. Brisson, et al.. Antibody-Functionalized Magnetic Polymersomes: In vivo Targeting and Imaging of Bone Metastases using High Resolution MRI. Advanced Healthcare Materials, 2013, 2 (11), pp.1420-1424. ⟨10.1002/adhm.201300061⟩. ⟨hal-00926530⟩
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