Oxytocin reverses ovariectomy-induced osteopenia and body fat gain. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Endocrinology Année : 2014

Oxytocin reverses ovariectomy-induced osteopenia and body fat gain.

Guillaume E Beranger
  • Fonction : Auteur
Didier F Pisani
Julien Castel
  • Fonction : Auteur
Mansour Djedaini
  • Fonction : Auteur
Séverine Battaglia
  • Fonction : Auteur
Jérôme Amiaud
  • Fonction : Auteur
Florian Boukhechba
  • Fonction : Auteur
Jean-François Michiels
  • Fonction : Auteur
Dominique Heymann
Serge Luquet
Ez-Zoubir Amri

Résumé

Osteoporosis and overweight/obesity constitute major worldwide public health burdens that are associated with aging. A high proportion of women develop osteoporosis and increased intraabdominal adiposity after menopause. which leads to bone fractures and metabolic disorders. There is no efficient treatment without major side effects for these 2 diseases. We previously showed that the administration of oxytocin (OT) normalizes ovariectomy-induced osteopenia and bone marrow adiposity in mice. Ovariectomized mice, used as an animal model mimicking menopause, were treated with OT or vehicle. Trabecular bone parameters and fat mass were analyzed using micro-computed tomography. Herein, we show that this effect on trabecular bone parameters was mediated through the restoration of osteoblast/osteoclast cross talk via the receptor activator of nuclear factor-κB ligand /osteoprotegerin axis. Moreover, the daily administration of OT normalized body weight and intraabdominal fat depots in ovariectomized mice. Intraabdominal fat mass is more sensitive to OT that sc fat depots, and this inhibitory effect is mediated through inhibition of adipocyte precursor's differentiation with a tendency to lower adipocyte size. OT treatment did not affect food intake, locomotors activity, or energy expenditure, but it did promote a shift in fuel utilization favoring lipid oxidation. In addition, the decrease in fat mass resulted from the inhibition of the adipose precursor's differentiation. Thus, OT constitutes an effective strategy for targeting osteopenia, overweight, and fat mass redistribution without any detrimental effects in a mouse model mimicking the menopause.

Dates et versions

hal-00968717 , version 1 (01-04-2014)

Identifiants

Citer

Guillaume E Beranger, Didier F Pisani, Julien Castel, Mansour Djedaini, Séverine Battaglia, et al.. Oxytocin reverses ovariectomy-induced osteopenia and body fat gain.. Endocrinology, 2014, 155 (4), pp.1340-52. ⟨10.1210/en.2013-1688⟩. ⟨hal-00968717⟩
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