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Article Dans Une Revue Journal of Virology Année : 2013

Fatal measles virus infection prevented by brain-penetrant fusion inhibitors.

Jeremy C Welsch
  • Fonction : co premier-auteur
Aparna Talekar
  • Fonction : co premier-auteur
Cyrille Mathieu
Antonello Pessi
  • Fonction : Auteur
Anne Moscona
Branka Horvat
Matteo Porotto

Résumé

Measles virus (MV) infection causes an acute childhood disease that can include infection of the central nervous system and can rarely progress to severe neurological disease for which there is no specific treatment. We generated potent antiviral peptide inhibitors of MV entry and spreading and MV-induced cell fusion. Dimers of MV-specific peptides derived from the C-terminal heptad repeat region of the MV fusion protein, conjugated to cholesterol, efficiently protect SLAM transgenic mice from fatal MV infection. Fusion inhibitors hold promise for the prophylaxis of MV infection in unvaccinated and immunocompromised people, as well as potential for the treatment of grave neurological complications of measles.

Dates et versions

hal-00972055 , version 1 (03-04-2014)

Identifiants

Citer

Jeremy C Welsch, Aparna Talekar, Cyrille Mathieu, Antonello Pessi, Anne Moscona, et al.. Fatal measles virus infection prevented by brain-penetrant fusion inhibitors.. Journal of Virology, 2013, 87 (24), pp.13785-94. ⟨10.1128/JVI.02436-13⟩. ⟨hal-00972055⟩
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