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Article Dans Une Revue European Journal of Immunology Année : 2013

S1PR5 is pivotal for the homeostasis of patrolling monocytes.

Thierry Walzer

Résumé

Patrolling Ly6C(-) monocytes are blood-circulating cells that play a role in inflammation and in the defense against pathogens. Here, we show that similar to natural killer (NK) cells, patrolling monocytes express high levels of S1PR5, a G-coupled receptor for sphingosine-1 phosphate. We found that S1pr5(-/-) mice lack peripheral Ly6C(-) monocytes but have a normal number of these cells in the bone marrow (BM). Various lines of evidence exclude a direct contribution of S1PR5 in the survival of Ly6C(-) monocytes at the periphery. Rather, our data support a role for S1PR5 in the egress of Ly6C(-) monocytes from the BM. In particular, we observed a reduced frequency of patrolling monocytes in BM sinusoids of S1PR5 KO mice. Unexpectedly, S1P was not a chemoattractant for patrolling monocytes and had no significant effect on their viability in vitro. Moreover, the disruption of S1P gradients in vivo did not alter Ly6C(-) monocyte trafficking and viability. These data suggest that S1PR5 regulates the trafficking of monocytes via a mechanism independent of S1P gradients.
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Dates et versions

hal-00972078 , version 1 (04-07-2017)

Identifiants

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Emilie Debien, Katia Mayol, Vincent Biajoux, Cécile Daussy, Mercedes Gomez de Aguero, et al.. S1PR5 is pivotal for the homeostasis of patrolling monocytes.. European Journal of Immunology, 2013, 43 (6), pp.1667-75. ⟨10.1002/eji.201343312⟩. ⟨hal-00972078⟩
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