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Article Dans Une Revue Chemical Communications Année : 2011

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.

Résumé

Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.

Domaines

Chimie organique
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Dates et versions

hal-00991912 , version 1 (16-05-2014)

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Citer

Guillaume Mercey, Tristan Verdelet, Géraldine Saint-André, Emilie Gillon, Alain Wagner, et al.. First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.. Chemical Communications, 2011, 47 (18), pp.5295-5297. ⟨10.1039/c1cc10787a⟩. ⟨hal-00991912⟩
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