Assessing sinus aerosol deposition: benefits of SPECT-CT imaging - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue International Journal of Pharmaceutics Année : 2014

Assessing sinus aerosol deposition: benefits of SPECT-CT imaging

Résumé

Purpose: Aerosol inhalation therapy is one of the methods to treat rhinosinusitis. However the topical drug delivery to the posterior nose and paranasal sinuses shows only limited efficiency. A precise sinusal targeting remains a main challenge for aerosol treatment of sinus disorders. This paper proposes a comparative study of the nasal deposition patterns of micron and submicron particles using planar gamma-scintigraphy imaging vs. a new 3-dimensional (3D) imaging approach based on SPECT-CT measurements. Methods: Radiolabelled nebulizations have been performed on a plastinated model of human nasal cast coupled with a respiratory pump. First, the benefits provided by SPECT-CT imaging were compared with 2D gamma-scintigraphy and radioactive quantification of maxillary sinus lavage as reference for the sonic 2.8 μm aerosol sinusal deposition. Then, the impact on nasal deposition of various airborne particle sizes was assessed. Results: The 2D methodology overestimates aerosol deposition in the maxillary sinuses by a factor 9 whereas the 3D methodology is in agreement with the maxillary sinus lavage reference methodology. Then with the SPECT-CT approach we highlighted that the higher particle size was mainly deposited in the central nasal cavity contrary to the submicron aerosol particles (33.8 ± 0.6% of total deposition for the 2.8 μm particles vs. 1 ± 0.3% for the 230 nm particles). Conclusion: Benefits of SPECT/CT for the assessment of radiolabelled aerosol deposition in rhinology are clearly demonstrated. This 3D methodology should be preferentially used for scintigraphic imaging of sinusal deposition in Human.
Fichier principal
Vignette du fichier
2014_leclerc_SPECT_IJP.pdf (1002.45 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01019021 , version 1 (08-07-2014)

Identifiants

Citer

Lara Leclerc, Jérémie Pourchez, Nathalie Prevot, Laurent Vecellio, Sandrine Le Guellec, et al.. Assessing sinus aerosol deposition: benefits of SPECT-CT imaging. International Journal of Pharmaceutics, 2014, 462 (1-2), pp.135-141. ⟨10.1016/j.ijpharm.2013.12.032⟩. ⟨hal-01019021⟩
405 Consultations
366 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More