Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Health and Quality of Life Outcomes Année : 2013

Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study

Résumé

Background: Responsiveness, defined as the ability to detect a meaningful change, is a core psychometric property of an instrument measuring quality of life (QoL) rarely reported in multiple sclerosis (MS) studies. Objective: To assess the responsiveness of the Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire to change in disability over 24 months, defined by change in the Expanded Disability Status Scale (EDSS) score. Methods: Patients with MS were enrolled into a multicenter, longitudinal observational study. QoL was assessed using both the MusiQoL and the 36-Item Short-Form (SF-36) instruments at baseline and every 6 months thereafter up to month 24; neurological assessments, including EDSS score, were performed at each evaluation. Results: The 24-month EDSS was available for 524 patients. In the 107 worsened patients, two specific dimensions of MusiQoL, the sentimental and sexual life and the relationships with health care system dimensions, and ‘physical’ scores of SF-36 showed responsiveness. Conclusions: Whereas specific dimensions of MusiQoL identified EDSS changes, the MusiQoL index did not detect disability changes in worsened MS patients in a 24-month observational study. Future responsiveness validation studies should include longer follow-up and more representative samples.
Fichier principal
Vignette du fichier
art_3A10.118_2F1477-7525-11-127.pdf (339.04 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-01096983 , version 1 (14-03-2017)

Identifiants

Citer

Karine Baumstarck, H Butzkueven, O Fernandez, P Flachenecker, S Stecchi, et al.. Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study. Health and Quality of Life Outcomes, 2013, 11, pp.127. ⟨10.1186/1477-7525-11-127⟩. ⟨hal-01096983⟩
41 Consultations
45 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More